I firmly believe that altering human DNA can be regarded as “playing” with mother nature, which is wrong. This is because nature dictates which genes are passed along to future generations, which is fair. Allowing any form of germline modification translates to opening doors to all kinds of gene-altering techniques, which is not prudent since gene-editing will escape from regulatory limits. Consequently, this will result in DNA altering procedures being used for enhancements reasons, which will increase discrimination, conflict, and inequality that is present in society.
It should be noted that making irreversible changes to all the cells in the bodies of the future generations all their descendants should be regarded as dangerous human experimentation. The rationale for this is that little is known regarding the effects of altering human DNA, such as off-target mutations and other long-term health and safety problems. Also, because altering DNA requires a viral vector that transfers well-functioning genes into the human body, many things are still unknown, such as where the functional gene will be placed. For instance, it is uncertain if altering human genes might result in the replacement of functional genes incase of defective ones.
The replacement of defective genes with functional ones might also result in the reduction of gene diversity. Studies indicate that if human beings have the same genome, then it might result in the entire population becoming susceptible to certain viruses or diseases. Also, genetic engineering could result in some unknown effects. For instance, published reports indicate that some alterations in plants or animals could result in unforeseen allergic reactions among people, which was not originally the case.