Physician-to-physician handoffs remains a high-risk aspect of patient care that is attributed to various safety events, poor care coordination, and medical errors. The situation predisposes the patient to several challenges including the incomplete transfer of information and lack of standardized procedure. Ineffective patient handoff contributes to the reliance on one-way communication, which is incomplete or delayed and can cause harm to the patient. Hospitals should overcome these challenges by implementing policies that promote education regarding handoffs. The roles of the sender and the receiver should be clearly defined to ensure that communication is reliable, complete, and effective. The handoff process is complex and incorporates a range of practitioners ranging from physicians, nurses, social workers, caregivers, among others. Additionally, patients suffering