Epidural anesthesis
Anesthesia is the loss of sensation without losing the consciousness .This is a regional that blocks pain in particular section of the bodies . Lidocaine being an epidural enthesis moves inside the cell binding sodium channel blocks the ion channel .Below paragraphs are discussing ion channel blocked lidocaine ,they impotance and how it alters conduction of the action potential.
To determine wich ion chenel is blockled by Lidocaine its of help to know which ion channels are beneficial in action potential. Between action potential conductance to pottusium ion and chlorine ion its high, thus chroline and potissum channels atre in in the nerve membraine. During upstroke voltage-gated sodium channel are most impotrant , repolarization resets both activation and inactivation of the sodium channel allowing the cell to open from the closed state not the inactivated state.This inhabits the movements of sodium ce;ll to nerve cell(Gupta et al.,2017).
Sodium channel are transmembrane proteins accountable for the rapid upstroke of the cardiac action potential, and also quick impulse conduction through cardiac tissue .They are responsible to the initiation and propagation in excitable cell including nerves and muscles .Sodium channels initiates action potential in nerve and other excitable cell(Chen et al.,2015) .Other key functions of voltage-gated sodium channels includes ;sodium selection and conductance ,voltage depandance activation and block by local anesthetics drugs.
Propagation of action potential is caused by limited current from depolarized region to adjacent inactive regions(Arzola et al., 2015) .this depolarizing current are triggered by inwatd sodium currrents of the upstroke of the action potential.when voltage-gated sodium channels is blocked by licodain ,they is no uccurence oof inward sodium current of the upstroke of the action potential . Hence prevention of the propagation of the action potential wich depends on depolarizing inward current.
References
Chen, W. K., Ren, L., Wei, Y., Zhu, D. X., Miao, C. H., & Xu, J. M. (2015). General anesthesia combined with epidural anesthesia ameliorates the effect of fast-track surgery by mitigating immunosuppression and facilitating intestinal functional recovery in colon cancer patients. International journal of colorectal disease, 30(4), 475-481.
Arzola, C., Mikhael, R., Margarido, C., & Carvalho, J. C. (2015). Spinal ultrasound versus palpation for epidural catheter insertion in labour: a randomised controlled trial. European Journal of Anaesthesiology (EJA), 32(7), 499-505.
Gupta, J. K., Sood, A., Hofmeyr, G. J., & Vogel, J. P. (2017). Position in the second stage of labour for women without epidural anaesthesia. Cochrane database of systematic reviews, (5).