Amal Albaqami Pre-Med A2 Ms. Ruth ENGL 211 Critique October 25, 2020 Bilgic, A. B., Gocmen, R., Arsava, E. M., & Topcuoglu, M. A. (2020). The Effect of Clot Volume and Permeability on Response to Intravenous Tissue Plasminogen Activator in Acute Ischemic Stroke. Journal of stroke and cerebrovascular diseases: the official journal of National Stroke Association, 29(2), 104541. Retrieved from https://doi.org/10.1016/j.jstrokecerebrovasdis.2019.104541 The response to Intravenous Tissue Plasminogen Activator (IV tPA) is highly determined by the size, content, and location in the clot, causing Acute Ischemic Stroke. In the article, The Effect of Clot Volume and Permeability on Response to Intravenous Tissue Plasminogen Activator in Acute Ischemic Stroke Bilgic et al. (2020) determined the interaction between IV tPA and